matrix metalloproteinases — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5361	T-26c		MMP
	T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor (IC50: 6.75 pM).		MMP
T16966	S 3304		MMP
	S 3304 is a novel matrix metalloproteinases inhibitor which is specific for MMP-2 and MMP-9.		MMP
T14978	CL-82198		MMP
	CL-82198, a selective MMP-13 inhibitor, serves as a pharmacological intervention to halt the progression of osteoarthritis (OA). Its mechanism of action involves binding to the S1’ pocket of MMP-13, ensuring its selectiv...		MMP
T4783	JNJ0966		MMP
	JNJ0966 is a highly selective MMP-9 zymogen inhibitor (IC50: 440 nM).		MMP
T3414	Morroniside		Apoptosis , MMP , Pyroptosis
	Morroniside would act as a regulator of hepatic inflammatory reactions and lipid metabolism in db/db mice. It exhibits protective effects against diabetic renal damage and human umbilical vein endothelial cells, by inhib...		Apoptosis , MMP , Pyroptosis
T8961	GW280264X	Carbamic acid	MMP
	GW280264X (Carbamic acid) is an inhibitor of ADAM17 .		MMP
T2009	SB-3CT		MMP
	SB-3CT is a potent and specific gelatinase inhibitor for MMP-2(Ki=13.9 nM) and MMP-9(Ki=600 nM).		MMP
T2993	Cordycepin	3'-Deoxyadenosine	MMP , TNF , Antibacterial , Antibiotic , Autophagy
	Cordycepin (3'-Deoxyadenosine) is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic activity.		MMP , TNF , Antibacterial , Antibiotic , Autophagy
T16124	MMP13-IN-3		MMP
	MMP13-IN-3 is >1000 selective over other MMPs. MMP13-IN-3 is an effective, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment of osteoarthritis.		MMP
T5416	T-5224		MMP
	T-5224 is a transcription factor c-Fos/AP-1 inhibitor, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors.		MMP
T22115	SM-7368		NF-κB
	The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.		NF-κB
T5983	O-Phenanthroline	1,10-Phenanthroline	MMP , Others
	o-Phenanthroline (1,10-Phenanthroline) , a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells.o-Phenanthroline protects mammalian cells from hydrogen peroxide-induced gene m...		MMP , Others
T4115	Auraptene	7-geranyloxycoumarin	MMP , BACE
	Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits le...		MMP , BACE
T6011	Batimastat	BB94	MMP
	Batimastat (BB94) (BB-94) is an effective, broad-spectrum matrix metalloprotease (MMP) inhibitor. Batimastat induces extracellular matrix degradation and inhibits angiogenesis, tumor growth and invasion, and metastasis.		MMP
T14322	ARP-100	MMP-2 Inhibitor III	MMP
	ARP-100 (MMP-2 Inhibitor III) is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with the S1' pocket of MMP-2 and exhibits anti-invasive properties in an in vitro invasion ...		MMP
T1891	NSC 405020		MMP
	NSC 405020 is a noncatalytic inhibitor of MT1-MMP.		MMP
TN1879	Lucideric acid A	Lucidenic acid A	MMP , p38 MAPK , JNK
	Lucideric acid A (Lucidenic acid A) is a modulator of JNK and p38 and enhances LPS-induced immune responses in monocytic THP-1 cells possibly via the modulation of p38 and JNK/MAPKs activation.		MMP , p38 MAPK , JNK
T8310	MMP-9-IN-1		MMP
	MMP-9-IN-1 is an inhibitor of specific matrix metalloproteinase-9 (MMP-9).		MMP
T7522	GI254023X	GI 254023X	MMP , Immunology/Inflammation related
	GI254023X is a potent MMP9 and ADAM10 inhibitor (IC50s: 2.5 and 5.3 nM) with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE). GI254023X can remarkably inhibit the proliferation and induce the apoptosis...		MMP , Immunology/Inflammation related
T2967	Stigmasterol	Stigmasterin,beta-Stigmasterol	MMP , Endogenous Metabolite
	Stigmasterol (Stigmasterin) is found in the fats and oils of soybean, calabar bean and rape seed, as well as several other vegetables, legumes, nuts, seeds, and unpasteurized milk. Stigmasterol has been focused on the ch...		MMP , Endogenous Metabolite